Is Clotrimazole Good for Vaginal Yeast Infection?

Is Clotrimazole Good for Vaginal Yeast Infection?


Clotrimazole is one of the most common medications for vaginal yeast infection. In this article, I’ll tell you what scientific research tells us about the efficacy of clotrimazole and what are the best OTC medications containing clotrimazole for vaginal yeast infection. I’ll also tell you what to do when clotrimazole doesn’t work.



How Effective is Clotrimazole? Facts:


  • A 2016 study compared the effectiveness of two doses of 500mg vaginal clotrimazole tablets and two doses of 150 mg oral fluconazole pills in treating severe vaginal yeast infection and they found out that. The cure rate after two weeks was 88.7% for clotrimazole treated women and 89.1% for women who took fluconazole. It shows that both medications are very effective in battling vaginal yeast infections, even in very severe cases.


  • A 2015 study shows that clotrimazole is very effective against Candida albicans (the most common culprit of vaginal yeast infections), but some Candida strains, such as Candida famata and Candida glabrata may be resistant to this medication.


Clotrimazole is very popular among women suffering from a yeast infection because in many cases a 3 to 7-day treatment is enough to clear the symptoms.



What are the Best OTC Medications With Clotrimazole?


Clotrimazole 3-Day Vaginal Cream


This 3-day treatment comes with 3 applicatorfuls of 2% clotrimazole cream and one tube of eternal clotrimazole cream.


Insert one applicatorful at bedtime for 3 consecutive days and use the external cream 2 times a day for up to 7 days to relieve external itching.


Is Clotrimazole Good for Vaginal Yeast Infection?


During your treatment abstain from sexual activity and don’t use tampons, douches or other vaginal products.  Clotrimazole 3-Day Vaginal Cream has got 80% of positive reviews on Amazon, so in most cases, it’s a very effective treatment.


If it doesn’t work, it could mean that you’ve got a Candida strain (not Candida albicans) which is resistant to clotrimazole. If you don’t see improvement within 7 days, make sure you see your doctor to have your vaginal swabs analyzed and find out what Candida strains is causing your infection.



Clotrimazole 7 Vaginal Cream 45 g


Clotrimazole 7 comes with seven applicatorfuls of clotrimazole to be used for 7 consecutive nights.


The concentration of clotrimazole in this cream is lower than that of Clotrimazole 3, but some women get better results with a longer and less concentrated treatment.


Is Clotrimazole Good for Vaginal Yeast Infection?


It’s important not to stop your treatment halfway as soon as your symptoms disappear. Stick to inserting the cream for 7 consecutive nights before going to bed to make sure that the infection doesn’t come back.




Can Clotrimazole Give any side Effects?


Clotrimazole can sometimes cause irritate the vagina walls, leaving them swollen and tender. If this side effect doesn’t disappear or worsens, you should see your doctor immediately.


Clotrimazole is unlikely to give a serious allergic reaction, but if you start feeling dizzy, have difficulty breathing and the treated area become itchy and swollen, seek medical help immediately.


Make sure you don’t use clotrimazole if you’re allergic to azole antifungal drugs, such as miconazole or itraconazole.


If you’re breastfeeding or pregnant, consult your doctor before starting your treatment to assess the risks and benefits of using clotrimazole or find an alternative treatment.


Order Your Yeast Infection Test Today


Where to Buy an OTC Yeast Infection Test Kit?


 Order online & test at home

 Collect & mail in your sample in 5 minutes

 Get lab-certified results on the go



Order Your Yeast Infection Test Today



What to do if Clotrimazole doesn’t Work?


If you don’t see any improvement after you finish your clotrimazole treatment it may be because your infection is caused by a Candida strain resistant to clotrimazole. In that case, you can try a different azole drug, such as miconazole. The most popular OTC with miconazole is called Monistat, you can check my review here.


Alternatively, you can try boric acid suppositories. Boric acid is very effective against some azole-resistant strains and it’s also used to treat bacterial vaginosis.


Is Clotrimazole Good for Vaginal Yeast Infection?


Boric acid treatment is 100% natural, however, it can sometimes give a burning sensation or irritate your skin.


According to Boricap Amazon reviews, most users are very happy with the results and they don’t experience any side effects.





All in all, clotrimazole is an economic and effective treatment option for the majority of women suffering from a yeast infection. If it doesn’t work, try Monistat or BoriCap.


Before starting your treatment, make sure that you’ve actually got a yeast infection and not bacterial vaginosis. in order to determine what sort of infection you’ve got, see your doctor to have your vaginal swabs analyzed or use a home test kit.


Order Clotrimazole 7 Today


In case it’s bacterial vaginosis you’re suffering from, clotrimazole or Monistat won’t work, but the good news is that BoriCap can work for both!


Please share your questions and experiences in the comment section below.


  • This doesn’t sound right: “It’s important to stop your treatment halfway as soon as your symptoms disappear. Stick to inserting the cream for 7 consecutive nights before going to bed to make sure that the infection doesn’t come back.” Surely you mean it’s important *not* to stop your treatment halfway.

  • Hi, if I only use Clotrimazole cream externally, will it eventually cure the yeast infection? I’m not comfortable using suppositories so I’m wondering if there are any other solutions.

    • Hi Adriana, using Clotrimazole cream externally will only help you relieve the external itching. Vaginal yeast infection starts inside the vagina so it has to be treated from the inside. If you’re not comfortable using suppositories, how about oral antifungal treatment? The most popular ones are Fluconazole and Itraconzaole, they’re both prescription drugs, so you’ll need to see your doctor to start your oral yeast infection treatment.

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